Catalyst-free synthesis of 伪1-oxindole-伪-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea was written by Molleti, Nagaraju;Yong Kang, Jun. And the article was included in Organic & Biomolecular Chemistry in 2016.Product Details of 20780-72-7 This article mentions the following:
A highly efficient phospha-aldol reaction for the synthesis of 伪1-oxindole-伪-hydroxyphosphonates is developed using N-heterocyclic phosphine (NHP)-thiourea as a phosphonylation reagent under catalyst, additive free conditions. This methodol. encompasses a variety of isatin derivatives to provide 伪1-oxindole- 伪-hydroxyphosphonates up to 99% yield. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Product Details of 20780-72-7).
4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Product Details of 20780-72-7
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles