Wang, Wanhe; Wu, Ke-Jia; Vellaisamy, Kasipandi; Leung, Chung-Hang; Ma, Dik-Lung published the article 《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》. Keywords: peptide conjugate theranostic imaging GRPr cancer immune cell; gastrin-releasing peptide receptor (GRPr); peptide-conjugated transition-metal complexes; theranostic agents; time-resolved emission spectroscopy.They researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Name: 2-Phenylpyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1008-89-5) here.
Gastrin-releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, the authors report a highly selective GRPr antagonist (JMV594)-tethered iridium(III) complex for probing GRPr in living cancer cells and immune cells. This probe exhibited desirable photophys. properties and also displayed negligible cytotoxicity, overcoming the inherent toxicity of the iridium(III) complex. Its long emission lifetime enabled its luminescence signal to be readily distinguished from the interfering fluorescence of organic dyes by using a time-resolved technique. This probe selectively visualized living cancer cells via specific binding to GRPr, while it also modulated the function of GRPr on TNF-α secretion in immune cells. To the authors′ knowledge, this is the first peptide-conjugated iridium(III) complex developed as a GRPr bioimaging probe and modulator of GRPr activity. This theranostic agent shows great potential at unmasking the diverse roles of GRPr in living systems.
The article 《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》 also mentions many details about this compound(1008-89-5)Name: 2-Phenylpyridine, you can pay attention to it, because details determine success or failure
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles