Application of 132098-59-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Enantioselective Free Radical Carbon-Carbon Bond Forming Reactions: Chiral Lewis Acid Promoted Acyclic Additions. Author is Wu, Jason Hongliu; Radinov, Rumen; Porter, Ned A..
The reaction of the acrylamide derived from the parent achiral oxazolidinone, I, with alkyl iodides (R-I), and allyltributylstannane has been investigated. The free radical reaction is promoted by Lewis acids such that clean conversion to the (1:1:1, R:I:allyl) adduct II, takes place in low temperature reactions initiated with triethylborane. In the presence of zinc triflate and chiral bis(oxazolines), III, derived from amino alcs., excellent yields of the (1:1:1) adduct are formed. Furthermore, this adduct is formed with good to excellent enantioselectivity. A model is suggested involving an intermediate complex of the radical, zinc ion, and the chiral ligand. The product is hydrolyzed and methylated to give the corresponding Me ester and the configuration of this ester is determined to be S if the bis(oxazoline) has the S,S configuration.
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles