Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C10H12O4, 2478-38-8, Name is Acetosyringone, molecular formula is C10H12O4, belongs to indole-building-block compound. In a document, author is Anokhin, Maksim V., introduce the new discover.
The Asymmetric Friedel-Crafts Reaction of Indoles with Arylidenemalonates Catalyzed by MgI2/PyBox Complexes
A mild and efficient catalytic enantioselective addition of indoles to dimethyl arylidenemalonates using MgI2 and PyBOX ligands bearing halogen substituents has been elaborated. The reactions were conducted in DCM at low temperature generally providing high yields (up to 99%), while enantioselectivity was shown to be strongly dependent on the nature of substituents in arylidenemalonate and indole reaching 83% ee. The reactivity of arylidenemalonates under described conditions was found to be enough different from that in copper-catalyzed Friedel-Crafts alkylation.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2478-38-8. Formula: C10H12O4.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles