In 2019.0 MOLECULES published article about TRANSITION-METAL-COMPLEXES; MOLECULAR DOCKING; RUTHENIUM(II) COMPLEXES; ANTICANCER ACTIVITY; CYTOTOXIC ACTIVITY; BINDING PROPERTIES; THERMAL-PROPERTIES; CRYSTAL-STRUCTURE; NI(II) COMPLEX; BSA-BINDING in [Li, Jiahe; Liu, Rongping; Jiang, Jinzhang; Liang, Xing; Huang, Ling; Ma, Zhen] Guangxi Univ, Sch Chem & Chem Engn, Nanning 530004, Guangxi, Peoples R China; [Li, Jiahe; Ma, Zhen] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, Av Rovisco Pais, P-1049001 Lisbon, Portugal; [Huang, Gang; Pan, Lixia] Guangxi Acad Sci, State Key Lab Nonfood Biomass & Enzyme Technol, Natl Engn Res Ctr Nonfood Biorefinery, Nanning 530004, Guangxi, Peoples R China; [Chen, Hailan] Guangxi Univ, Sch Anim Sci & Technol, Nanning 530004, Guangxi, Peoples R China in 2019.0, Cited 85.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. HPLC of Formula: C7H6O2
A series of ZnCl2 complexes (compounds 1-10) with 4′-(substituted-phenyl)-2,2′:6′,2 ”-terpyridine that bears hydrogen (L-1), p-methyl (L-2), p-methoxy (L-3), p-phenyl (L-4), p-tolyl (L-5), p-hydroxyl (L-6), m-hydroxyl (L-7), o-hydroxyl (L-8), p-carboxyl (L-9), or p-methylsulfonyl (L-10) were prepared and then characterized by H-1 NMR, electrospray mass-spectra (ESI-MS), IR, elemental analysis, and single crystal X-ray diffraction. In vitro cytotoxicity assay was used to monitor the antiproliferative activities against tumor cells. Absorption spectroscopy, fluorescence titration, circular dichroism spectroscopy, and molecular modeling studied the DNA interactions. All of the compounds display interesting photoluminescent properties and different maximal emission peaks due to the difference of the substituent groups. The cell viability studies indicate that the compounds have excellent antiproliferative activity against four human carcinoma cell lines, A549, Bel-7402, MCF-7, and Eca-109, with the lowest IC50 values of 0.33 (10), 0.66 (6), 0.37 (7), and 1.05 (7) mu M, respectively. The spectrophotometric results reveal that the compounds have strong affinity binding with DNA as intercalator and induce DNA conformational transition. Molecular docking studies indicate that the binding is contributed by the pi…pi stacking and hydrogen bonds, providing an order of nucleotide sequence binding selectivity as ATGC > ATAT > GCGC. These compounds intercalate into the base pairs of the DNA of the tumor cells to affect their replication and transcription, and the process is supposed to play an important role in the anticancer mechanism.
HPLC of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Li, JH; Liu, RP; Jiang, JZ; Liang, X; Huang, L; Huang, G; Chen, HL; Pan, LX; Ma, Z or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles