Let¡¯s face it, organic chemistry can seem difficult to learn, HPLC of Formula: C9H10O4, Especially from a beginner¡¯s point of view. Like 306-08-1, Name is Homovanillic Acid, molecular formula is indole-building-block, belongs to indole-building-block compound. In a document, author is Chen, Lili, introducing its new discovery.
Synthesis of cyclic chiral alpha-amino boronates by copper-catalyzed asymmetric dearomative borylation of indoles
A copper(i)-catalyzed dearomative borylation of N-alkoxycarbonyl protected indole-3-carboxylates has been developed. The boron addition in this reaction occurred regioselectively at the 2-position of indoles followed by diastereoselective protonation, affording the corresponding stable cyclic chiral -amino boronates (2-borylindolines) in moderate to good yields with excellent diastereo- and enantioselectivities. The product 2c could be used as a versatile precursor to undergo subsequent stereoselective transformations, delivering highly functionalized 2,3,3-trisubstituted chiral indolines.
If you are hungry for even more, make sure to check my other article about 306-08-1, HPLC of Formula: C9H10O4.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles