Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 1143532-39-1, Name is AZD5363, molecular formula is , belongs to indole-building-block compound. In a document, author is Su, Rongkui, Computed Properties of C21H25ClN6O2.
Annulation Cascades of N-Allyl-N-((2-bromoaryl)ethynyl)amides Involving C-H Functionalization
An annulation cascades of N-allyl-N-((2-bromoaryl)ethynyl)amides with terminal alkynes or 1,3-dicarbonyls involving C-H functionalization for producing 2,3-functionalized indoles has been first developed by means of Cu catalysis. The method is enabled by the formation of the ketenimine intermediates to deliver 2,3-disubstituted indoles through a sequence of aza-Claisen rearrangement, C-H functionalization, Ullmann C-N coupling, and cyclization.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles