Morzyk-Ociepa, Barbara et al. published their research in Polyhedron in 2014 | CAS: 4382-54-1

5-Methoxyindole-2-carboxylic acid (cas: 4382-54-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Related Products of 4382-54-1

Crystal structure, infrared and EPR spectra and anticancer activity in vitro of the novel manganese(II) complexes of indolecarboxylic acids was written by Morzyk-Ociepa, Barbara;Kokot, Mariusz;Rozycka-Sokolowska, Ewa;Gielzak-Kocwin, Krystyna;Filip-Psurska, Beata;Wietrzyk, Joanna;Michalska, Danuta. And the article was included in Polyhedron in 2014.Related Products of 4382-54-1 This article mentions the following:

The new complexes of 5-methoxyindole-2-carboxylic acid (5-MeOI2CAH) and indole-2-carboxylic acid (I2CAH) with manganese(II): catena-poly[diaquamanganese(II)-bis(渭2-5-methoxyindole-2-carboxylato-O:O’)], [Mn(5-MeOI2CA)2(H2O)2]n (1) and catena-poly[diaquamanganese(II)-bis(渭2-indole-2-carboxylato-O:O’)], [Mn(I2CA)2(H2O)2]n (2) have been prepared A single crystal x-ray anal. of 1 shows that the complex crystallizes in the monoclinic system, space group P21/c. The 5-MeOI2CA anion acts as a bidentate bridging ligand coordinated to Mn(II) in an abnormal non-planar skew-skew mode, which differs from the coplanar syn-syn, syn-anti and anti-anti bridging modes commonly occurring in metal carboxylates. The FTIR and EPR spectroscopic studies of Mn(II) complexes are reported. In vitro cytotoxicities of 1, 2, 5-MeOI2CAH, I2CAH and their Zn(II) complexes have been evaluated by an MTT assay against the selected human leukemia cell lines: HL-60, MV-4-11, U937, Jurkat, KG-1, U2932 and murine melanoma B16-F0. The two manganese(II) complexes are cytotoxic and their antiproliferative activity against some cell lines (e.g. Jurkat derived from an acute T cell leukemia) is similar to that of cisplatin. In the experiment, the researchers used many compounds, for example, 5-Methoxyindole-2-carboxylic acid (cas: 4382-54-1Related Products of 4382-54-1).

5-Methoxyindole-2-carboxylic acid (cas: 4382-54-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Related Products of 4382-54-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles