On February 13, 2020, Na, Hyo Gyeong; Imran, Ali; Kim, Kyuneun; Han, Hong Sik; Lee, Young Jin; Kim, Myung-Jin; Yun, Chang-Soo; Jung, Young-Sik; Lee, Joo-Youn; Han, Soo Bong published an article.Name: Methyl 5-bromoindoline-7-carboxylate The title of the article was Discovery of a New Sulfonamide Hepatitis B Capsid Assembly Modulator. And the article contained the following:
Hepatitis B virus (HBV) remains a major health concern with 260 million people having been infected globally, and approx. 680,000 deaths have occurred annually from cirrhosis and liver cancer. The modulation of HBV capsid assembly has emerged as a promising therapeutic approach for curing chronic HBV infection. Small-mol. capsid assembly modulators (CAMs) can broadly be classified as heteroaryldihydropyrimidines and sulfamoylbenzamides (SBAs). SBAs are capsid activators that inhibit viral replication by achieving capsid assembly before polymerase encapsulation. Herein, we report a novel series of HBV CAMs based on NVR 3-778, a potent CAM belonging to the SBA class. The lead compound (KR-26556) exhibited improved pharmacol. activity and was examined through mol. docking studies. The experimental process involved the reaction of Methyl 5-bromoindoline-7-carboxylate(cas: 860624-88-0).Name: Methyl 5-bromoindoline-7-carboxylate
The Article related to hepatitis b capsid assembly antihbv mol docking studies, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Name: Methyl 5-bromoindoline-7-carboxylate
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles