Application of 120-72-9In 2021 ,《Indole derivatives (2010-2020) as versatile tubulin inhibitors: synthesis and structure-activity relationships》 appeared in Future Medicinal Chemistry. The author of the article were Naaz, Fatima; Neha, Kumari; Haider, Rafi Md; Shafi, Syed. The article conveys some information:
A review. Tubulin inhibitors are conjugates that interfere with the dynamic equilibrium of the polymerization and depolymerization of microtubules. Among all the reported conjugates, indole moiety is one of the most significant classes for the development of new drug candidates for cancer therapy. Due to their presence in a wide range of natural as well as synthetic antitubulin agents, indole has become a versatile scaffold in research, and various synthetic and semisynthetic indole-based antitubulin agents have been identified and reported. The present article focuses on the reported indole-based tubulin inhibitors of synthetic origin from last the decade. Synthesis, structure-activity relationships and biol. activities of synthetic indole derivatives along with brief updates on their antitubulin activity are presented. The experimental process involved the reaction of 1H-Indole(cas: 120-72-9Application of 120-72-9)
1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 120-72-9
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles