On January 7, 2019, Nakamura, Hidemitsu; Hirabayashi, Kei; Miyakawa, Takuya; Kikuzato, Ko; Hu, Wenqian; Xu, Yuqun; Jiang, Kai; Takahashi, Ikuo; Niiyama, Ruri; Dohmae, Naoshi; Tanokura, Masaru; Asami, Tadao published an article.Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole The title of the article was Triazole Ureas Covalently Bind to Strigolactone Receptor and Antagonize Strigolactone Responses. And the article contained the following:
Strigolactones, a class of plant hormones with multiple functions, mediate plant-plant and plant-microorganism communications in the rhizosphere. In this study, we developed potent strigolactone antagonists, which covalently bind to the strigolactone receptor D14, by preparing an array of triazole urea compounds Using yeast two-hybrid and rice-tillering assays, we identified a triazole urea compound KK094 as a potent inhibitor of strigolactone receptors. Liquid chromatog.-tandem mass spectrometry anal. and X-ray crystallog. revealed that KK094 was hydrolyzed by D14, and that a reaction product of this degradation covalently binds to the Ser residue of the catalytic triad of D14. Furthermore, we identified two triazole urea compounds KK052 and KK073, whose effects on D14-D53/D14-SLR1 complex formation were opposite due to the absence (KK052) or presence (KK073) of a trifluoromethyl group on their Ph ring. These results demonstrate that triazole urea compounds are potentially powerful tools for agricultural application and may be useful for the elucidation of the complicated mechanism underlying strigolactone perception. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole
The Article related to oryza tillering triazole urea strigolactone signaling, covalent antagonist, crystal structure, strigolactone, triazole urea, Agrochemical Bioregulators: Plant and other aspects.Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles