2-Amino-3-(7-methyl-1H-indol-3-yl)propanoic acid (cas: 17332-70-6) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.COA of Formula: C12H14N2O2
Deracemization and Stereoinversion to Aromatic D-Amino Acid Derivatives with Ancestral L-Amino Acid Oxidase was written by Nakano, Shogo;Minamino, Yuki;Hasebe, Fumihito;Ito, Sohei. And the article was included in ACS Catalysis in 2019.COA of Formula: C12H14N2O2 This article mentions the following:
Enantiomerically pure amino acid derivatives could be foundational compounds for peptide drugs. Deracemization of racemates to L-amino acid derivatives can be achieved through the reaction of evolved D-amino acid oxidase and chem. reductants, whereas deracemization to D-amino acid derivatives has not progressed due to the difficulty associated with the heterologous expression of L-amino acid oxidase (LAAO). In this study, we succeeded in developing an ancestral LAAO (AncLAAO) bearing broad substrate selectivity (13 L-amino acids) and high productivity through an Escherichia coli expression system (∼50.7 mg/L). AncLAAO can be applied to perform deracemization to D-amino acids in a similar way to deracemization to L-amino acids. In fact, full conversion (>99% ee, D-form) could be achieved for 16 racemates, including nine D,L-Phe derivatives, six D,L-Trp derivatives, and a D,L-phenylglycine. Taken together, we believe that AncLAAO could be a key enzyme to obtain optically pure D-amino acid derivatives in the future. In the experiment, the researchers used many compounds, for example, 2-Amino-3-(7-methyl-1H-indol-3-yl)propanoic acid (cas: 17332-70-6COA of Formula: C12H14N2O2).
2-Amino-3-(7-methyl-1H-indol-3-yl)propanoic acid (cas: 17332-70-6) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.COA of Formula: C12H14N2O2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles