Total Synthesis of (±)-Aspergilline A was written by Nakhla, Mina C.;Wood, John L.. And the article was included in Journal of the American Chemical Society in 2017.Product Details of 20780-72-7 This article mentions the following:
The total synthesis of (±)-aspergilline A (I) is described. Key features of the synthesis include pyrrolinone formation via reaction of an intermediate propargyl amine with a Me malonyl chloride derived ammonium enolate and a formal [3+2] cycloaddition between an imidate and cyclopropenone. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Product Details of 20780-72-7).
4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Product Details of 20780-72-7
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles