Neel, David A.’s team published research in Bioorganic & Medicinal Chemistry Letters in 8 | CAS: 149108-61-2

Bioorganic & Medicinal Chemistry Letters published new progress about 149108-61-2. 149108-61-2 belongs to indole-building-block, auxiliary class Indole,Boronic acid and ester,Sulfamide,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (1-tosyl-1H-Indol-3-yl)boronic acid, and the molecular formula is C15H14BNO4S, Synthetic Route of 149108-61-2.

Neel, David A. published the artcileSynthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction, Synthetic Route of 149108-61-2, the publication is Bioorganic & Medicinal Chemistry Letters (1998), 8(1), 47-50, database is CAplus and MEDLINE.

Bis(indolyl)maleimides are known to be potent and selective PKC inhibitors. A new synthesis of this class of compound is reported. One of the target compounds was 3-(1H-indol-3-yl)-1-methyl-4-(1-methyl-1H-indol-3-yl)-1H-Pyrrole-2,5-dione. The key step is a Suzuki cross-coupling reaction using a readily available indolylmaleimide triflate intermediate.

Bioorganic & Medicinal Chemistry Letters published new progress about 149108-61-2. 149108-61-2 belongs to indole-building-block, auxiliary class Indole,Boronic acid and ester,Sulfamide,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (1-tosyl-1H-Indol-3-yl)boronic acid, and the molecular formula is C15H14BNO4S, Synthetic Route of 149108-61-2.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles