Liu, GK; Li, X; Qin, WB; Peng, XS; Wong, HNC; Zhang, LX; Zhang, XH in [Liu, Guo-Kai; Li, Xin; Qin, Wen-Bing] Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China; [Peng, Xiao-Shui; Wong, Henry N. C.] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Zhang, Linxing; Zhang, Xinhao] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Lab Computat Chem & Drug Design, Shenzhen 518055, Peoples R China published Facile difluoromethylation of aliphatic alcohols with an S-(difluoro-methyl)sulfonium salt: reaction, scope and mechanistic study in 2019, Cited 42. Recommanded Product: 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
A facile and practical approach for the difluoromethylation of aliphatic alcohols with an S-(difluoromethyl)sulfonium salt was developed. A wide variety of alcohols with broad functional groups are compatible to furnish the corresponding alkyl difluoromethyl ethers in good to excellent yields under mild reaction conditions. Control experiments and DFT computational studies suggest that the difluoromethylation of alcohols mainly proceeds via a difluorocarbene pathway involving a five-membered transition state with the participation of water, whose crucial role in this reaction was also elucidated by control experiments.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles