Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 149-91-7, Name is 3,4,5-Trihydroxybenzoic acid, SMILES is OC1=CC(C(O)=O)=CC(O)=C1O, belongs to indole-building-block compound. In a document, author is Shaikh, Nadim S., introduce the new discover, Computed Properties of C7H6O5.
Discovery and pharmacological evaluation of indole derivatives as potent and selective ROR gamma t inverse agonist for multiple autoimmune conditions
Targeting nuclear receptor ROR gamma is recognized to be beneficial in multiple autoimmune disorders. We disclosed new indole analogues as potent ROR gamma inverse agonists. RO-2 as one of the potent and orally bioavailable compounds was evaluated in various models of autoimmune disorder. It showed potent suppression of downstream markers of ROR gamma t activity in murine and human primary cells, ex vivo PD assay and in multiple animal models of autoimmune diseases. The results indicate the potential of these indole analogues as orally bioavailable small molecule inverse agonists of ROR gamma t, efficacious in various Th17 driven models of autoimmune disorders.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 149-91-7 is helpful to your research. Computed Properties of C7H6O5.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles