Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Cobalt-mediated synthesis of 2-(4-pyridyl)benzimidazole. X-ray structures of Co[2-(4-pyridyl)benzimidazole]2(H2O)2(NO3)2 and [Co(isonicotinate)(4-pyridinium carboxylate)(H2O)(NO3)]∞. Author is Wang, Zhiyong; Wilson, Scott R.; Foxman, Bruce M.; Lin, Wenbin.
We have observed an unusual example of cobalt-mediated cyclization of 4-pyridinecarboxaldehyde and 2-nitroaniline to afford 2-(4-pyridyl)benzimidazole under hydro(solvo)thermal conditions. Reaction of Co(NO3)2·6H2O with 4-pyridinecarboxaldehyde and 2-nitroaniline in ethanol at 120° gave a cobalt(II) coordination compound, Co[2-(4-pyridyl)benzimidazole]2(H2O)2(NO3)2 (I). In contrast, when the hydro(solvo)thermal reaction was carried out between Co(NO3)2·6H2O and isonicotinic acid in the presence of 2-nitroaniline at 110°, a one-dimensional Co(II) coordination polymer with the formula of [Co(isonicotinate)(4-pyridinium carboxylate)(H2O)(NO3)]∞ (II) resulted. The x-ray single crystal structures of both I and II are described. Interestingly, the isonicotinic acid in II exists as a 4-pyridinium carboxylate tautomer, and the pyridinium hydrogen atom forms a very strong hydrogen bond to the carboxylate oxygen of the 4-pyridinium carboxylate on an adjacent metal center. I forms a three-dimensional polymeric network through hydrogen bonding interactions, while II exists as a 2-D bilayer polymeric network through hydrogen bonding interactions.
After consulting a lot of data, we found that this compound(2208-59-5)Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles