In 2019.0 BIOORG MED CHEM LETT published article about HEPATOCELLULAR-CARCINOMA; HEPATITIS-B; BOSENTAN; CANCER; RISK in [Zhao, Shuangmei; Zhen, Yongqi; Fu, Leilei; Gao, Feng; Zhou, Xianli; Huang, Shuai; Zhang, Lan] Southwest Jiaotong Univ, Sch Life Sci & Engn, 111 North Second Ring Rd, Chengdu 610031, Sichuan, Peoples R China in 2019.0, Cited 22.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Product Details of 100-83-4
Sodium taurocholate cotransport polypeptide (NTCP) plays an important role in the development of hepatitis and acts as a switch to allow hepatitis virus to enter hepatic cells. As the entry receptor protein of hepatitis virus, NTCP is also an effective target for the treatment of hepatocellular carcinoma. Herein, twenty-five benzamide analogues were synthesized based on the virtual screening design and their anti-proliferative activities against HepG2 cells were evaluated in vitro. Compound 35 was found to be promising, with an IC50 value of 2.8 mu M. The apoptosis induced by 35 was characterized by the regulation of markers, including an increase in Box, cleaved-caspase 3, and cleaved-PARP proteins, and a decrease in Bcl-2 protein. Molecular docking and molecular dynamics (MD) simulation confirmed that compound 35 can bind tightly to NTCP. Western blot analysis also showed that NTCP was inhibited. Altogether, these results indicate that compound 35 acts as a novel NTCP inhibitor to induce apoptosis in HepG2 cells.
Welcome to talk about 100-83-4, If you have any questions, you can contact Zhao, SM; Zhen, YQ; Fu, LL; Gao, F; Zhou, XL; Huang, S; Zhang, L or send Email.. Product Details of 100-83-4
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles