Safety of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide, is researched, Molecular C21H14Br4O5S, CAS is 76-60-8, about Spectroscopic determination of free-base nicotine in e-liquids.
In order to rapidly characterize the free-base nicotine (FBN) in e-liquids, two indicators, bromocresol green (BCG) and chlorophenol red (CPR), which could provoke color reactions with FBN, were employed to develop a spectroscopic method for FBN quantification in e-liquids The developed method was compared with the pH method and the NMR method. The results showed that the two color indicators were weakly acidic and could bind with FBN but not with protonated nicotine, thus indicating the mass fraction of FBN. The correlations between the spectroscopic responses and the mass fraction of FBN in e-liquids were established based on this principle. The calibration curve was lgA616 = 0.0172c – 0.5378 (r2 = 0.9989, LOD = 0.11 mg/g, LOQ = 0.37 mg/g) when adopting BCG, while the calibration curve for CPR was lgA587 = 0.0154c – 0.8130 (r2 = 0.9936, LOD = 0.19 mg/g, LOQ = 0.63 mg/g). Sixteen com. e-liquid samples were tested using the developed method. The average proportion of FBN (αfbn) in e-liquids was 19.2% for the e-liquids with higher than 20 mg/g nicotine and 76.1% for those with lower than 20 mg/g nicotine. In addition, the mass fractions of FBN obtained by this method were higher than those by the pH method when αfbn was lower. There was a good correlation between the FBN mass fractions obtained by the spectroscopic method and by the NMR method. As an indicator, CPR was better than BCG. The spectrometry method can realize the rapid and visual determination of FBN in e-liquids
After consulting a lot of data, we found that this compound(76-60-8)Safety of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles