An article Alkylsulfenyl thiocarbonates: precursors to hydropersulfides potently attenuate oxidative stress WOS:000652175600001 published article about HYDROGEN-SULFIDE; CYSTEINE PERSULFIDES; CARBONYL SULFIDE; CHEMICAL BIOLOGY; POLYSULFIDES; REACTIVITY; TOXICITY; DONORS in [Khodade, Vinayak S.; Aggarwal, Sahil C.; Pharoah, Blaze M.; Toscano, John P.] Johns Hopkins Univ, Dept Chem, Charles & 34Th St, Baltimore, MD 21218 USA; [Paolocci, Nazareno] Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD 21205 USA; [Paolocci, Nazareno] Univ Padua, Dept Biomed Sci, Padua, Italy in 2021.0, Cited 46.0. Quality Control of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
The recent discovery of the prevalence of hydropersulfides (RSSH) species in biological systems suggests their potential roles in cell regulatory processes. However, the reactive and transient nature of RSSH makes their study difficult, and dependent on the use of donor molecules. Herein, we report alkylsulfenyl thiocarbonates as a new class of RSSH precursors that efficiently release RSSH under physiologically relevant conditions. RSSH release kinetics from these precursors are tunable through electronic modification of the thiocarbonate carbonyl group’s electrophilicity. In addition, these precursors also react with thiols to release RSSH with a minor amount of carbonyl sulfide (COS). Importantly, RSSH generation by these precursors protects against oxidative stress in H9c2 cardiac myoblasts. Furthermore, we demonstrate the ability of these precursors to increase intracellular RSSH levels.
Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Khodade, VS; Aggarwal, SC; Pharoah, BM; Paolocci, N; Toscano, JP or concate me.
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