In an article, author is Kumar, Sumit, once mentioned the application of 3895-92-9, Recommanded Product: Chelerythrine Chloride, Name is Chelerythrine Chloride, molecular formula is C21H18ClNO4, molecular weight is 383.8249, MDL number is MFCD00060717, category is indole-building-block. Now introduce a scientific discovery about this category.
The present paper describes the synthesis, anti-plasmodial, and cytotoxic evaluation of 7-chloroquinoline-based conjugates with isatins/indoles/ nitroimidazoles, obtainedviaCu-promoted 1,3-dipolar cycloadditions. On contemplating SAR of the synthesized series, the inclusion of indole and nitroimidazole-core improved the anti-plasmodial activities while the isatin seemed to have a lesser effect. The conjugate with a nitroimidazole-core and hexyl chain length as a spacer between the two pharmacophores was found to be most potent among the synthesized series and displayed an IC50 of 0.12 mu M and a selectivity index of 1748.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles