99-50-3, Name is Protocatechuic acid, molecular formula is C7H6O4, belongs to indole-building-block compound, is a common compound. In a patnet, author is Hazenberg, Mette D., once mentioned the new application about 99-50-3, Quality Control of Protocatechuic acid.
Stool can soften GVHD
In this issue of Blood, Swimm et al report that the tryptophan metabolite indole that is produced by the intestinal microbiome limits graft-versus-host disease (GVHD). In mouse models of GVHD, they found that indoles act via type I interferons (IFNs) to limit chemotherapy- and radiotherapy-induced damage to the intestinal epithelium.(1)
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles