Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 132098-59-0, is researched, SMILESS is C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1, Molecular C19H18N2O2Journal, Article, Chemical Communications (Cambridge, United Kingdom) called Copper-catalyzed asymmetric alkynylation of cyclic N-sulfonyl ketimines, Author is Ling, Zheng; Singh, Sonia; Xie, Fang; Wu, Liang; Zhang, Wanbin, the main research direction is alkynylation asym cyclic sulfonyl ketimine copper catalyst; benzisothiazole asym preparation alkynylation cyclic sulfonyl ketimine copper catalyst.Recommanded Product: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane.
A Cu-catalyzed asym. alkynylation of cyclic N-sulfonyl ketimines I (R1 = Et, Me, n-Bu, CHMe2, R2 = H, 5-Me, 7-OCF3, 4,6-Me2, etc.) was developed, providing the corresponding chiral α-tertiary amines II (R3 = Ph, 2-ClC6H4, 4-FC6H4, 2-thienyl, etc.) with up to 98% ee. The method tolerates some variations in cyclic N-sulfonyl ketimine and alkyne scope. These products could be used in several transformations, in particular, the products of 6-membered cyclic N-sulfonyl ketimines could be easily converted to linear chiral α-tertiary amines. This asym. alkynylation provides an efficient, gram-scale, low-cost transition-metal catalyzed synthesis of chiral α-tetrasubstituted propargylamines.
In some applications, this compound(132098-59-0)Recommanded Product: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles