Application of 21799-87-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 21799-87-1, Name is Potassium 2,5-dihydroxybenzenesulfonate, SMILES is [K+].OC1=CC(=C(O)C=C1)S([O-])(=O)=O, belongs to indole-building-block compound. In a article, author is Kona, Chandrababu Naidu, introduce new discover of the category.
Iridium-Catalyzed Direct C4-and C7-Selective Alkynylation of Indoles Using Sulfur-Directing Groups
Indoles and their analogues have been one of the most ubiquitous heterocycles during the past century, and extensive studies have been conducted to establish practical synthetic methods for their derivatives. In particular, selective functionalization of the poorly reactive benzenoid core over the pyrrole ring has been a great challenge. Reported herein is an iridium-catalyzed direct alkynylation of the indole C4- and C7-positions with the assistance of sulfur directing groups. This transformation shows a wide range of functional-group tolerance with exceptional site selectivity. The directing group can be either easily removed or transformed after catalysis. The synthetic utility of the alkyne fragment is demonstrated by the derivatization into the core structure of natural indole alkaloids.
Application of 21799-87-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 21799-87-1 is helpful to your research.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles