The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 896466-04-9, Name is AT9283, SMILES is O=C(NC1CC1)NC1=CNN=C1C1=NC2=C(N1)C=CC(CN1CCOCC1)=C2, in an article , author is Kumar, Raju Suresh, once mentioned of 896466-04-9, Computed Properties of https://www.ambeed.com/products/896466-04-9.html.
Two series of dimethoxyindanone imbedded novel fluorinated spiropyrrolidine heterocyclic hybrids were synthesized employing two different less explored azomethine ylides and were measured for their efficiency as inhibitors for Alzheimer’s disease. Among the spiropyrrolidine heterocyclic hybrids, the indole based fluorinated compound with a methoxy substituent at the metaposition of the aryl ring exhibited the utmost potent AChE and BChE inhibitory activities with an IC50 of 1.97 0.19 mM and 7.08 +/- 0.20 mM respectively. The plausible mechanism of inhibition on ChE receptors was unveiled via molecular docking studies. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles