Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 497-76-7, Name is Arbutin, molecular formula is C12H16O7, belongs to indole-building-block compound. In a document, author is Tarasenko, Elena A., introduce the new discover, Recommanded Product: Arbutin.
Enantioselective Copper(II)/Box-catalyzed Synthesis of Chiral beta(3)-Tryptophan Derivatives
beta-Amino acids and their derivatives are important building blocks for the preparation of various bioactive compounds and materials. We developed a highly efficient method for the synthesis of beta(3)-tryptophan derivatives based on enantioselective Friedel-Crafts alkylation of indoles with phthaloyl-protected aminomethylenemalonate in the presence of chiral Cu(OTf)(2)/iPrBox complex as a catalyst. A wide range of indoles with electron-donating and electron-withdrawing substituents gave the desired products in high yields (up to 99 %) and excellent enantioselectivities (up to 99 % ee). In the case of pyrrole the Friedel-Crafts product was obtained in up to 90 % yield and up to 82 % ee.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 497-76-7. Recommanded Product: Arbutin.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles