Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 541-91-3, Name is Muscone, molecular formula is C16H30O. In an article, author is Karoutzou, Olga,once mentioned of 541-91-3, SDS of cas: 541-91-3.
Synthesis of New Indole and Adamantane Amido Derivatives with Pharmacological Interest
The synthesis and preliminary pharmacological evaluation of new indole and adamantane amido derivatives is described. The design was based on the pharmacophoric properties of 4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl), 6-[4-(trifluoro methoxy)phenyl]pyridin-3-yl and 4-(trifluoro)phenyl tails, which are present as side chains in the structures of promising drug candidates, currently in clinical tests. These pharmacophores were incorporated into the indole and adamantane scaffolds, respectively. The new derivatives were evaluated for their antimycobacterial potential. The following amides, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-{4-[4(trifluoromethoxy)phenoxy]piperidin-1-yl}benzamide (1 b) and N-{4-[4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl]benzyl}-1H-indolyl-2-carboxamide (2 b), are endowed with antitubercular properties, which merit further investigation.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles