An article A regioselective [4+2] annulation approach to 5-acylindolizine-7-carbonitriles: generation of poly-substituted pyridines WOS:000659907800001 published article about BIOLOGICAL EVALUATION; CHEMICAL SPACE; INDOLIZINES; DERIVATIVES; INHIBITORS; CASCADE; YLIDES in [Kim, Sunmi; Lee, Jeong Hwa; Kim, Ikyon] Yonsei Univ, Coll Pharm, 85 Songdogwahak Ro, Incheon 21983, South Korea; [Kim, Sunmi; Lee, Jeong Hwa; Kim, Ikyon] Yonsei Univ, Yonsei Inst Pharmaceut Sci, 85 Songdogwahak Ro, Incheon 21983, South Korea; [Yoon, Seok Hyun] Yonsei Univ, Grad Program Ind Pharmaceut Sci, 85 Songdogwahak Ro, Incheon 21983, South Korea in 2021, Cited 46. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
The reaction of beta-ketonitrile and N-substituted pyrrole-2-carboxaldehyde in the presence of piperidinium acetate in CH3CN permitted regioselective access to 5-acylindolizine-7-carbonitrile through a domino Knoevenagel condensation-intramolecular aldol cyclization sequence. A wide range of new indolizine derivatives with a poly-functionalized pyridine moiety were readily synthesized in an atom-economical fashion, thereby expanding the indolizine chemical space for further applications.
Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Kim, S; Lee, JH; Yoon, SH; Kim, I or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles