Electric Literature of 15861-24-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 15861-24-2, Name is Indole-5-carbonitrile, molecular formula is C9H6N2. In a Article£¬once mentioned of 15861-24-2
The synthesis and biological evaluation of unsymmetrical 2,2-di(1H-indol-3-yl)-N-phenylacetamide derivatives
A mild and highly efficient method has been developed for the synthesis of unsymmetrical 2,2-di(1H-indol-3-yl)-N-phenylacetamide derivatives by the regioselective Friedel-Crafts alkylation of 2-hydroxy-2-(1H-indol-3-yl)-N-phenylacetamide derivatives with various indoles catalyzed by AlCl3 at room temperature in a short reaction time in high yields (up to 96%). All these compounds were screened for their antiproliferative activity against human colorectal carcinoma HCT116 cell line. The preliminary biological study showed that some of them exhibited moderate to good antiproliferative activity in vitro. Especially, compound 3e exerted the most powerful antiproliferative activity even better than the positive control MDM-2/p53 antagonist Nutlin-3a.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 15861-24-2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 15861-24-2, in my other articles.
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles