Let’s face it, organic chemistry can seem difficult to learn, Formula: https://www.ambeed.com/products/50-35-1.html, Especially from a beginner’s point of view. Like 50-35-1, Name is Thalidomide, molecular formula is indole-building-block, belongs to indole-building-block compound. In a document, author is Jiang, Xinpeng, introducing its new discovery.
A practical conversion of indoles into the corresponding 2-oxindoles is achieved efficiently using a hypervalent iodine reagent. This oxidation is amenable to different substituted indoles, and allows the synthesis of a wide range of synthetically valuable substituted 2-oxindoles in up to 90% yield. Furthermore, Ropinirole, a drug used to alleviate the symptoms of Parkinson’s disease, was synthesized in three steps in an overall yield of 44% using this method.
If you are hungry for even more, make sure to check my other article about 50-35-1, Formula: https://www.ambeed.com/products/50-35-1.html.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles