With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10075-50-0,5-Bromoindole,as a common compound, the synthetic route is as follows.
General procedure: NaH (6.1 mmol, 1.2 equiv) was slowly added to a solution of 5-bromoindole/indazole (5.1 mmol,1 equiv) in DMF (10 mL) at 0 ¡ãC. The mixture was stirred at 0 ¡ãC for 10 min then the alkylhalide (6.1 mmol, 1.2 equiv) was added at the same temperature. The reaction mixture wascontinued to stir at rt for 2 h. When the reaction was complete [TLC (EtOAc/hexane 1:5)], themixture was extracted with EtOAc (2 ¡Á 20 mL) and washed with water (2 ¡Á 20 mL). The organiclayer was separated, dried over anhydrous Na2SO4 and the solvent removed under reducedpressure. The residue obtained was purified by flash column chromatography [silica gel (230?400 mesh; Merck), EtOAc/hexane 1:5].
The synthetic route of 10075-50-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Narayanarao, Manjunatha; Koodlur, Lokesh; Revanasiddappa, Vijayakumar G.; Gopal, Subramanya; Kamila, Susmita; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2893 – 2897;,
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