With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1011-65-0,Methyl 1H-indole-5-carboxylate,as a common compound, the synthetic route is as follows.,1011-65-0
Production Example 7 A 1.28 ml portion of phosphoryl chloride was added dropwise to 8 ml ofN,N-dimethylformamide under ice-cooling, followed by stirring at room temperature for 15 minutes. An 8 ml portion of an N,N-dimethylformamide solution of 2.00 g of methyl 1H-indole-5-carboxylate was added dropwise to this solution under ice-cooling, followed by stirring at room temperature for 1.5 hours. Under ice-cooling, 50 ml of water was added thereto and potassium carbonate was further added until the pH became 12, and the resulting solid was collected by filtration, washed with water and then dried over heating under a reduced pressure to obtain 2.19 g of methyl 3-formyl-1H-indole-5-carboxylate as a pale light brown solid.
The synthetic route of 1011-65-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Astellas Pharma Inc.; EP1988076; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles