With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101495-18-5,4,6-Dichloro-1H-indole,as a common compound, the synthetic route is as follows.
To a mixture of 4,6-dichloro-1H-indole (0.5 g, 2.69 mmol) in AcOH (5 mL) was added NaBH3CN (557 mg, 8.87 mmol) at 0 C., and then the mixture was stirred at 25 C. for 12 h under an N2 atmosphere. The reaction mixture was quenched by the addition of ice water (20 mL) at 0 C., and then saturated aq. NaOH was added to the mixture to adjust the pH to 8. The reaction mixture was extracted with DCM (100 mL*2). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2, petroleum ether/ethyl acetate=30:1 to 5:1), 4,6-Dichloroindoline (0.1 g, 531.7 mumol, 19.7% yield) was obtained as yellow oil.
101495-18-5, The synthetic route of 101495-18-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Cervello Therapeutics LLC; Lee, Matthew Randolph; Varano, JR., Anthony Joseph; (53 pag.)US2020/140412; (2020); A1;,
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