105191-12-6, 6-Bromo-1H-indole-2-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 150mL equipped with a magnetic stirrerIn a round bottom flask, 6-bromo-1H-indole-2-carbaldehyde (Compound 1) (8.07 g, 36.00 mmol), 4-methyl-3-oxopentanoate (Compound 2) (5.70 g) , 36.03 mmol), isopropanol (21.1 mL), piperidine (2.2 mL) and glacial acetic acid (1.2 mL). The reaction mixture was stirred at room temperature under nitrogen for 12 h.The solvent was removed under reduced pressure. The residue was taken in dichloromethane (13.88 mL)Dissolve and wash with saturated NaHCO3 (3*30 mL) solution. After drying over anhydrous MgSO4, MgSO4 was removed by filtration. After concentrating the solvent under reduced pressure, the column was separated by flash column chromatography. Obtained an off-white solid (Z)-2-((6-bromo-1H-indol-2-yl)methylene)-4-methyl-3-oxopentanoate (Compound 3), 12.46 g The yield is 95%.
105191-12-6, As the paragraph descriping shows that 105191-12-6 is playing an increasingly important role.
Reference£º
Patent; Meng Xiaoxu; (12 pag.)CN108689989; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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