1074-86-8, 1H-Indole-4-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
K2CO3 (19.2 g, 138.93 mmol) and 2-fluorobenzonitrile (9.18 g, 75.87 mmol) were added to a solution of 24 (10 g, 68.97 mmol) in 100 mL DMF. The mixture was stirred and refluxed for 1 h. After cooling to rt, the mixture was added to 100 mL water and extracted with ethyl acetate (100 mL * 3). After that the organic phase was collected and washed with NaCl saturated solution (150 mL * 5) and then dried over MgSO4. After filtration, the solvent was removed under reduced pressure. The residue was recrystallized by ethyl acetate to obtain white solid. Yield: 89.1percent. MP: 240-243 ¡ãC. 1H NMR (400 MHz, CDCl3) delta: 10.32 (s, 1H), 7.91 (d, 1H), 7.81 (t, 1H), 7.76 (d, 1H), 7.61-7.56 (m, 5H), 7.42 (t, 1H). MS (ESI): [M + H]+ calcd 247.1; found 247.2.
1074-86-8, As the paragraph descriping shows that 1074-86-8 is playing an increasingly important role.
Reference£º
Article; Zhu, Weibo; Bao, Xiaolu; Ren, He; Da, Yajing; Wu, Dan; Li, Fuming; Yan, Yijia; Wang, Li; Chen, Zhilong; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 161 – 178;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles