With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1196-70-9,1H-Indole-6-carbaldehyde,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 5 (0.2 mmol) in anhydrous THF, NaH (60%,0.24 mmol) was added at 0 C under N2 atmosphere. After stirring for15 min, aromatic aldehyde (0.24 mmol) was added into the mixture andthe reaction was stirred for another 1 h. The reaction mixture was thenextracted with EtOAc (3¡Á20 mL). The combined organic layers werethen washed with saturated brine, dried over anhydrous Na2SO4, andconcentrated in vacuo. The residue was purified by flash columnchromatography using PE/EA (5/1, V/V) as an eluent to afford thecompounds 7a-n, 8a-d.
1196-70-9, 1196-70-9 1H-Indole-6-carbaldehyde 2773435, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Li, Wenlong; Sun, Honghao; Xu, Feijie; Shuai, Wen; Liu, Jie; Xu, Shengtao; Yao, Hequan; Ma, Cong; Zhu, Zheying; Xu, Jinyi; Bioorganic Chemistry; vol. 85; (2019); p. 49 – 59;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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