With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1196-70-9,1H-Indole-6-carbaldehyde,as a common compound, the synthetic route is as follows.
1196-70-9, Step 3. Synthesis of (E)-N?-(( 1 H-indol-6-yl)methylene)-2-(2-(furan-3 -yl)-6- methylphenoxy)acetohydrazide: 2-(2-(furan-3 -yl)-6-methylphenoxy)acetohydrazide (70 mg,0.28 mmol) and 1H-indol-6-carbaldehyde (45 mg, 0.31 mmol) were dissolved in EtOH 2 mL, followed by stirring at 100 C for 12 hours. After the completion of the reaction, the reaction mixture was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (ethyl acetate:hexane = 1:1) to obtain Compound 313 (20 mg, 19%).?H NMR (400 MHz, DMSO-d6): 6 11.41 (m, 2H), 8.45-8.01 (2s, IH), 8.30 (m, IH), 7.72 (m,1H), 7.46 (m, 4H), 7.10 (m, 4H), 6.44 (m, 1H), 4.70 (s, 1H), 4.25 (s, 1H), 2.30 (m, 3H).
1196-70-9 1H-Indole-6-carbaldehyde 2773435, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; CHOI, HoJin; LEE, JaeWon; LEE, ChangGon; HA, NiNa; SEO, Su Kil; LEE, SunMi; LEE, Song-Min; WO2014/35149; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles