143612-79-7, 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
under nitrogen protection,A commercially available 6.8 g of 3- (4-chlorobutyl) -5-cyanoindole was dissolved in 70 mL of ether with 8.9 g of cuprous iodide to form a reaction solution,Heated to reflux for 3.5 hours.Then the commercially available 5.9g5-piperazine-benzofuran 2-carboxylate and60 g of sodium methoxide was added to the stirred reaction solution,The reaction solution was reacted at 90 C for 5.5 hours until TLC was complete.The reaction solution was cooled to room temperature and poured slowlyStirring in 100 mL of aqueous potassium hydroxide solution, a large amount of yellow solid precipitated and precipitatedThe solid reaction solution was stirred for 1 hour and then filtered to obtain a filter cake which was washed with 50 mL of waterAfter three runs, 8.9 g of 5- (4- [4- (5-cyano-3-indolyl) -butyl] -1-piperazinyl)Benzofuran-2-carboxylate., 143612-79-7
143612-79-7 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile 9881123, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; Suzhou Uugene Biopharma Co., Ltd.; Hu, Fan; Wang, Shenyong; Shao, Changkun; Li, Sheng; Wang, Xiaojun; Hu, Junkai; (12 pag.)CN103360373; (2016); B;,
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