With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-49-2,3-Indoleglyoxylic Acid,as a common compound, the synthetic route is as follows.
The reagents used for each of the amide bond formation was amino core (4 mumol), carboxylic acid (4 mumol, 1 eq.), DIEA (5 mumol, 1.2 eq.) and HBTU (4.5 mumol, 1.1eq.). A stock of the amino core for synthesis of 102 members requires an amount in excess of 150 fold. Both the starting amino core and the carboxylic acids were prepared as a stock solution of DMSO in a concentration of 0.6 mmol/1500 muL and 4 mumol/10 muL, respectively. HBTU and DIEA were dissolved in DMSO as a concentration of 4.5 mumol/10 muL (V/V) and 5 mumol/10 muL (V/V), respectively. Each of the acid portion was firstly mixed with the solution of HBTU in a plastic tube for 30 sec, followed by the addition of a mixture of the solution of amino core (4 mumol, 10 muL) and DIEA (10 muL) in a total volume of 40 muL. All vials were shaken for 1 min ultrasonically for the subsequent series dilution., 1477-49-2
The synthetic route of 1477-49-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Su, Yuan-Hsiao; Chiang, Li-Wu; Jeng, Kee-Ching; Huang, Ho-Lien; Chen, Jenn-Tzong; Lin, Wuu-Jyh; Huang, Chia-Wen; Yu, Chung-Shan; Bioorganic and Medicinal Chemistry Letters; vol. 21; 5; (2011); p. 1320 – 1324;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles