With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-49-2,3-Indoleglyoxylic Acid,as a common compound, the synthetic route is as follows.
1477-49-2, General procedure: To a solution of carboxylic acid (2.05 equiv.), diamine (1 equiv.), and PyBOP (2.05 equiv.) in DMF (1 mL) was added Et3N (3 equiv.). The reaction mixture was allowed to stir under N2 at room temperature for 23 h. The solution was dried in vacuo and the crude reaction product purified by C8 reversed-phase column chromatography (20%-30% MeOH/H2O (+0.05%TFA)) to afford the target diamide as the bis-trifluoroacetate salt or by silica gel column chromatography (0%-1% MeOH in CH2Cl2) to afford the target diamide as the free base.
The synthetic route of 1477-49-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wang, Jiayi; Kaiser, Marcel; Copp, Brent R.; Marine Drugs; vol. 12; 6; (2014); p. 3138 – 3160;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles