With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.162100-95-0,6-Fluoro-5-methyl-1H-indole,as a common compound, the synthetic route is as follows.
Synthesis of intermediate 14a:A solution of 6-fluoro-5-methyl-1 H-indole [CAS 162100-95-0] (880 mg, 5.9 mmol) in CH2CI2 (50 mL) was cooled to 0C under N2-atmosphere. A solution ofdiethylalunninunn chloride 1 M in hexane (8.85 mL, 8.85 mmol) was added dropwise and the resulting mixture was kept at 0C for 15 min. A solution of 2-(4-fluoro-2- methoxyphenyl)acetyl chloride 1a (1 .67 g, 8.26 mmol) in CH2CI2 (25 mL) was added dropwise. Stirring was continued at 0C for 1 h and the reaction mixture was subsequently stirred at room temperature for 2 h. The reaction mixture was poured out in a stirring ice/Rochelle salt solution. The mixture was filtered over dicalite and the filter cake was washed several times with THF. The filtrates were combined. The layers were separated and the organic layer was washed with brine and water, dried over MgSO4, filtered and evaporated under reduced pressure. The solid residue was suspended in CH2CI2 (30 ml_). The precipitate was filtered off, washed with a small amount of CH2CI2 and dried under vacuum at 50C to provide 2-(4-fluoro-2-methoxyphenyl)-1 -(6-fluoro-5-methyl-1 H-indol-3- yl)ethanone 14a (1 .22 g)., 162100-95-0
The synthetic route of 162100-95-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; KESTELEYN, Bart, Rudolf, Romanie; BONFANTI, Jean-Francois; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; BARDIOT, Dorothee, Alice, Marie-Eve; MARCHAND, Arnaud, Didier, M; (86 pag.)WO2016/113371; (2016); A1;,
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