With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192189-07-4,tert-Butyl 3-iodo-1H-indole-1-carboxylate,as a common compound, the synthetic route is as follows.
Triethyl borate (2.92 g, 20 mmol) was dissolved in tetrahydrofuran (20 mL) Cooled to -78 C, n-butyllithium (2.4 mol / L, 8.33 mL, 20 mmol) Stirred for half an hour, tert-butyl 3-iodo-lH-indole-1-carboxylate (3.43 g, LOmmol), slowly rose to room temperature, stirred for 2 hours, TLC detection of raw materials disappeared. Add water, ethyl acetate extraction, combined organic phase, Dried over anhydrous sodium sulfate, and the solvent was removed by rotary evaporation to give crude (2.61 g) Without purification directly for the next step, 192189-07-4
The synthetic route of 192189-07-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wu Yongqian; (29 pag.)CN104876914; (2017); B;,
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