21296-93-5, 5-Chloro-2,3-dimethyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Organic urea catalyst (2S) -2-[[[[[3,5-bis (trifluoromethyl) phenyl] amino] oxomethyl] amino] -N- (diphenylmethyl) -N, 3,3-trimethylbutyramide (44.8 mg, 0.08 mmol), 2,3-dimethyl-5-chloroindole (71.8 mg, 0.4 mmol), diphenyl phosphate (9.8 mg, 0.04 mmol) and A molecular sieve (199.5 mg) was dissolved in n-hexane (16 mL), and then ethyl trifluoropyruvate (106 muL, 0.8 mmol) was added. The reaction was carried out at room temperature for 42.5 hours. The reaction equation is as follows:The reaction solution was filtered through silica gel, rinsed with ether, and concentrated. Silica gel column chromatography was used to obtain 112 mg of a solid product. The calculated yield was 80%. The measured er value was 93: 7, and n-hexane / dichloromethane (1: 1) was used. ) Recrystallization, mother liquor was concentrated to obtain 100 mg of liquid product, the calculated yield was 72%, and the er value was 96: 4., 21296-93-5
The synthetic route of 21296-93-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Hong Kong University Of Science And Technology Shenzhen Institute; Sun Jianwei; Ma Dengke; (35 pag.)CN110437126; (2019); A;,
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