221352-46-1, 2-(tert-Butoxycarbonyl)isoindoline-1-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution ofHATU (1.83 g, 4.82 mmol) in DMF (15 mL) was added Hunig’s base(2.34 mL, 13.1 mmol). After stirring for 5 min, racemic 2-(tert-butoxycarbonyl)isoindoline-1-carboxylic acid 2-1 (1.15 g, 4.38 mmol) and ammonium chloride (1.41 g, 26.3 mmol) wereadded to the mixture. The reaction was stirred at room temperature for 18 h. The reaction waspartitioned between EtOAc (20 mL) and water (20 mL). The layers were separated and theaqueous layer was extracted with EtOAc (2 x 20 mL). The combined organic layer waswashed with brine, dried over MgS04, filtered and concentrated. The residue was purified by silica gel chromatography (IS CO 120 g column) eluting with a hexanes/EtOAc gradient (0 to100% EtOAc) to afford the title compound. LRMS mlz (M+H) 263.2 found, 263.1 required., 221352-46-1
The synthetic route of 221352-46-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; GRESHOCK, Thomas, J.; MULHEARN, James, J.; ROECKER, Anthony, J.; JIAN, Tianying; ZHOU, Gang; GUO, Liangqin; WON, Walter; ZHANG, Ting; ANAND, Rajan; STELMACH, John, E.; WANG, Deping; KIM, Ronald, M.; LAYTON, Mark, E.; BURGEY, Christopher, S.; NANTERMET, Philippe, G.; (129 pag.)WO2018/93694; (2018); A1;,
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