230291-43-7, Methyl 4-chloro-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of methyl 4-chloro-li -indole-2-carboxylate (5.30 g, 25.2 mmol) and potassium carbonate (10.4 g, 75.8 mmol) inN,N-dimethylformamide (70.0 mL) was added methyl iodide (10.7 g, 75.8 mmol) and the reaction mixture was stirred at 60 C for 4 hrs. On completion, the reaction mixture was concentrated in vacuo to give a crude product, which was purified by silica gel chromatography (petroleum ether : ethyl acetate = 5: 1) to give the title compound. NMR (400MHz, DMSO-d6) delta = 7.63 (d, J= 8.4 Hz, 1H), 7.36 (t, J= 8.0 Hz, 1H), 7.28 – 7.17 (m, 2H), 4.06 (s, 3H), 3.88 (s, 3H).
230291-43-7, The synthetic route of 230291-43-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (358 pag.)WO2017/156165; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles