32588-36-6, Indole-2-acetic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of 1,3,4,6-tetra-O-acetyl-b-D-glucosamine (1equiv) in dry CH2Cl2 at 00C under an N2 atmosphere was addedEDC.HCl (1.2 equiv), HOBT (1.2 equiv), Et3N (0.5 equiv) and carboxylicacid (1.2 equiv). The reaction mixture was stirred at room temperature for 24 h and upon consumption of the starting material;the reaction mixture was poured into ice-water (300 mL) andstirred vigorously for 20 min. The precipitate was collected via filtration and washed with ice cold water to afford the amide products as white solids. 4.2.5.1. (2S,3R,4S,5S,6R)-6-(acetoxymethyl)-3-(4-phenylbutanamido)tetrahydro-2H-pyran-2,4,5-triyl triacetate (8a). The title compoundwas synthesized from acetoxy glucosamine 7 (1.00 g, 2.88 mmol)and 4-phenylbutyric acid (0.57 g, 3.45 mmol) following GSP-1 toyield a white solid (1.17 g, 82%). M.p. 159-160 C; Optical rotation:[a]25589 + 25.0 (MeOH); 1H NMR (300 MHz, DMSO-d6): d 1.68-1.79 (m,2H, CH2), 1.90 (s, 3H, CH3), 1.98 (s, 3H, CH3), 2.01 (s, 3H, CH3), 2.02 (s,3H, CH3), 1.93-2.06 (m, 2H, CH2), 2.48-2.50 (m, 2H, CH2), 3.93-3.97(m, 2H, CH2), 3.98-4.02 (m, 1H, CH), 4.2 (dd, J = 4.9, 4.9 Hz, 1H, CH),4.90 (t, J = 9.6 Hz, 1H, CH), 5.21 (t, J = 10.0 Hz, 1H, CH), 5.75 (d,J = 8.8 Hz, 1H, CH), 7.15-7.20 (m, 3H, 3 ArCH), 7.26-7.31 (m, 2H,2 ArCH), 8.00 (d, J = 9.4 Hz, 1H, NH); 13C NMR (75 MHz,DMSO-d6): d 20.8 (CH3), 20.9 (CH3), 21.0 (2 CH3), 27.5 (CH2),34.8 (CH2) 35.4 (CH2), 52.3 (CH), 61.9 (CH2), 68.6 (CH), 72.0 (CH),72.6 (CH), 92.2 (CH), 126.3 (ArCH), 128.7 (2 ArCH), 128.8(2 ArCH), 142.0 (ArC), 169.3 (CO), 169.7 (CO), 170.0 (CO), 170.5(CO), 172.6 (CO); IR (neat): mmax 912, 1031, 1220, 1369, 1529,1656, 1739, 3333 cm1; HRMS (+ESI): Found m/z 516.1841[M+Na]+, C24H31NO10Na requires 516.1840.
32588-36-6, The synthetic route of 32588-36-6 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Biswas, Nripendra N.; Yu, Tsz Tin; Kimyon, Oender; Nizalapur, Shashidhar; Gardner, Christopher R.; Manefield, Mike; Griffith, Renate; Black, David StC.; Kumar, Naresh; Bioorganic and Medicinal Chemistry; vol. 25; 3; (2017); p. 1183 – 1194;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles