New learning discoveries about 366017-09-6

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In an article, author is Huo, Zong-Qing, once mentioned the application of 366017-09-6, Safety of Mubritinib, Name is Mubritinib, molecular formula is C25H23F3N4O2, molecular weight is 468.47, MDL number is MFCD09954135, category is indole-building-block. Now introduce a scientific discovery about this category.

Bousangine A, a novel C-17-nor aspidosperma-type monoterpenoid indole alkaloid from Bousigonia angustifolia

Two new monoterpenoid indole alkaloids, bousangines A (1) and B (2), were isolated from the twigs and leaves of Bousigonia angustifolia. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Bousangine A (1) possessed a rearrangement pentacyclic skeleton derived from aspidosperma-type alkaloids with C-17 degradation. Their antiproliferative activity against several human cancer cell lines were evaluated.

If you are interested in 366017-09-6, you can contact me at any time and look forward to more communication. Safety of Mubritinib.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles