387-43-9, 4-Fluoroindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: Preparation of 4-fluoro-1-tosyl-1H-indole (F-1) [0329] To a flask was added 4-fluoro-1H-indole (1000 mg, 7.40 mmol), sodium hydride (326 mg, 8.14 mmol), and DMF (14.8 mL). The solution was allowed to stir at room temperature for 30 min. 4-methylbenzene-1-sulfonyl chloride (2116 mg, 11.10 mmol) was then added to the flask and the resulting solution was allowed to stir for 3 hours. The mixture was diluted with ethyl acetate, washed 2¡Á with aqueous sodium hydrogen carbonate and 1¡Á with brine. The combined aqueous layer was back extracted once with ethyl acetate, combined organic layers were dried with Na2SO4, filtered and the solvent was evaporated under reduced pressure. The residue was purified by flash chromatography (EtOAc/Hexane 0-75percent) to give the desired product as a colorless solid. (1.76 g, 82percent) LCMS (ESI) calc’d for C15H12FNO2S [M+H]+: 290. found: 290. .
As the paragraph descriping shows that 387-43-9 is playing an increasingly important role.
Reference£º
Patent; Barr, Kenneth J.; Maclean, John K.; Zhang, Hongjun; Beresis, Richard T.; Zhang, Dongshan; Andresen, Brian M.; Anthony, Neville J.; Lapointe, Blair T.; Sciammetta, Nunzio; US2015/191434; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles