In 2019.0 EUR J ORG CHEM published article about OXIDATIVE TRIFLUOROMETHYLATION; H TRIFLUOROMETHYLATION; MEDIATED TRIFLUOROMETHYLATION; AROMATIC-COMPOUNDS; LACCASE; ARENES; FLUORINE; REAGENT; HETEROARENES; REACTIVITY in [Pletz, Jakob; Koeberl, Christoph; Fuchs, Michael; Kroutil, Wolfgang] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, BioTechMed Graz, Heinrichstr 28, A-8010 Graz, Austria; [Steiner, Oliver; Goessler, Walter] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Univ Pl 1-1, A-8010 Graz, Austria in 2019.0, Cited 54.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. HPLC of Formula: C8H8O2
Fluorination and trifluoromethylation are indispensable tools in the preparation of modern pharmaceuticals and APIs. Herein we present a concept for the introduction of a trifluoromethyl group into unprotected phenols employing catalytic copper(I) iodide and hydroquinone, tBuOOH, and the Langlois’ reagent. The method proceeds under mild conditions and exhibits an extended substrate scope compared to the biocatalytic trifluoromethylation using laccase from Agaricus bisporus. Various functional groups such as aldehydes, esters, ethers, ketones and nitriles were tolerated. The hydroquinone-mediated trifluoromethylation reaction allowed accessing trifluoromethylated phenols, which are cumbersome to prepare via previously known chemical methods.
HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Pletz, J; Koeberl, C; Fuchs, M; Steiner, O; Goessler, W; Kroutil, W or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles