436091-59-7, 4-Bromo-7-methoxy-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 2:A solution of indole 52b (619 mg, 2.7 mmol) in DMF (5 mL) at 230C is treated with NaH (60% in oil dispersion, 125 mg, 5.2 mmol) and stirred at 230C for 5 min. Ethyl bromoacetate (637 muL, 5.75 mmol) is added and the solution is stirred at 230C for 24 h; UPLC/MS analysis indicated 62 % conversion. To this mixture, additional amounts of NaH (60% in oil dispersion, 77 mg, 1.9 mmol) and ethyl bromoacetate (244 muL, 2.2 mmol) are added. After 10 min, the UPLC analysis indicated > 90% conversion. The reaction is diluted with EtOAc, washed with saturated NH4CI solution and brine (4X), dried over MgSO4, filtrated, concentrated and purified by flash chromatography (5-20 %; EtOAc/hexanes) to give 52c (541 mg, 63 % yield) as a yellow oil., 436091-59-7
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Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; WO2009/62285; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles